CD39/CD73/A2AR pathway and cancer immunotherapy

Abstract Cancer development is closely associated with immunosuppressive tumor microenvironment (TME) that attenuates antitumor immune responses and promotes tumor cell immunologic escape. The sequential conversion of extracellular ATP into adenosine by two important cell-surface ectonucleosidases C...

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Bibliographic Details
Main Authors: Chenglai Xia, Shuanghong Yin, Kenneth K. W. To, Liwu Fu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12943-023-01733-x