CD39/CD73/A2AR pathway and cancer immunotherapy

CD39/CD73/A2AR pathway and cancer immunotherapy

Abstract Cancer development is closely associated with immunosuppressive tumor microenvironment (TME) that attenuates antitumor immune responses and promotes tumor cell immunologic escape. The sequential conversion of extracellular ATP into adenosine by two important cell-surface ectonucleosidases C...

Full description

Bibliographic Details
Main Authors:	Chenglai Xia, Shuanghong Yin, Kenneth K. W. To, Liwu Fu
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Series:	Molecular Cancer
Subjects:	Immunosuppressive tumor microenvironment Cancer immunotherapy CD39 CD73 Adenosine receptor A2AR
Online Access:	https://doi.org/10.1186/s12943-023-01733-x

Similar Items

Current perspectives and trends of CD39-CD73-eAdo/A2aR research in tumor microenvironment: a bibliometric analysis
by: Tian Huang, et al.
Published: (2024-08-01)

The CD39/CD73/Adenosine and NAD/CD38/CD203a/CD73 Axis in Cutaneous T-Cell Lymphomas
by: Liyun Lin, et al.
Published: (2025-02-01)

Research progress of CD39-CD73-adenosine pathway in immune regulation of hepatocellular carcinoma
by: Lin SUN, et al.
Published: (2024-12-01)

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy
by: Xuan Jiang, et al.
Published: (2023-01-01)

Inhibitors of the CD73-adenosinergic checkpoint as promising combinatory agents for conventional and advanced cancer immunotherapy
by: Zoya Kurago, et al.
Published: (2023-06-01)

Cytokine-Induced Killer Cells Express CD39, CD38, CD203a, CD73 Ectoenzymes and P1 Adenosinergic Receptors
by: Alberto L. Horenstein, et al.
Published: (2018-04-01)

T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis
by: Yang X, et al.
Published: (2025-01-01)

Adenosine signaling: Optimal target for gastric cancer immunotherapy
by: Junqing Wang, et al.
Published: (2022-09-01)

Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer
by: Carla Fernanda Furtado Gardani, et al.
Published: (2023-11-01)

The potential role of purinergic signaling in cancer therapy: perspectives on anti-CD73 strategies for prostate cancer
by: Carla Fernanda Furtado Gardani, et al.
Published: (2024-09-01)

Assessment of CD4<sup>+</sup> cells subpopulations with the expressing CD39 and CD73 ectonucleotidases in children with psoriasis
by: D. G. Kuptsova, et al.
Published: (2022-07-01)

Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response
by: María Angels Ortiz, et al.
Published: (2023-12-01)

The Role of Cluster of Differentiation 39 (CD39) and Purinergic Signaling Pathway in Viral Infections
by: Alaa Elsaghir, et al.
Published: (2023-02-01)

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73<sup>-</sup> Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes
by: Parimah Ahmadi, et al.
Published: (2020-07-01)

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors
by: Laura Schäkel, et al.
Published: (2020-09-01)

Adenosinergic axis and immune checkpoint combination therapy in tumor: A new perspective for immunotherapy strategy
by: Zhaoyun Liu, et al.
Published: (2022-09-01)

CHARACTERIZATION OF DIFFERENTIAL EXPRESSION PATTERNS OF THE EXTRACELLULAR PURINERGIC ENZYMES IN COLORECTAL CANCER
by: Serkan Göktuna
Published: (2022-10-01)

CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease
by: Igor Kudryavtsev, et al.
Published: (2019-07-01)

Inversed Ratio of CD39/CD73 Expression on γδ T Cells in HIV Versus Healthy Controls Correlates With Immune Activation and Disease Progression
by: Katharina Kolbe, et al.
Published: (2022-04-01)

CD73: a new immune checkpoint for leukemia treatment
by: Huan Gao, et al.
Published: (2025-03-01)

The roles of adenosine signaling in systemic lupus erythematosus
by: Ke Dong, et al.
Published: (2024-05-01)

PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES
by: A. S. Golovkin, et al.
Published: (2018-06-01)

The yin and yang functions of extracellular ATP and adenosine in tumor immunity
by: Li-li Feng, et al.
Published: (2020-04-01)

Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis
by: Xiang F, et al.
Published: (2025-01-01)

CD73, a significant protein in liver diseases
by: Huilian Shi, et al.
Published: (2023-04-01)

Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors
by: Andrea M Chambers, et al.
Published: (2022-07-01)

Intratumoral CD73: An immune checkpoint shaping an inhibitory tumor microenvironment and implicating poor prognosis in Chinese melanoma cohorts
by: Zixu Gao, et al.
Published: (2022-09-01)

Adenosine Signaling in Autoimmune Disorders
by: Giulia Magni, et al.
Published: (2020-09-01)

Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction
by: Marius Witt, et al.
Published: (2024-12-01)

A2AR Expression and Immunosuppressive Environment Independent of <i>KRAS</i> and <i>GNAS</i> Mutations in Pseudomyxoma Peritonei
by: Shigeki Kusamura, et al.
Published: (2023-07-01)

A role for EMT in CD73 regulation in breast cancer
by: Meriem Hasmim, et al.
Published: (2022-12-01)

Eosinophils and Purinergic Signaling in Health and Disease
by: Davide Ferrari, et al.
Published: (2020-07-01)

Comprehensive pan-cancer analysis of CD73: Explore its association with prognosis and tumor immune microenvironment
by: Chen Chen, et al.
Published: (2024-11-01)

The Multifaceted Actions of CD73 During Development and Suppressive Actions of Regulatory T Cells
by: Meihong Da, et al.
Published: (2022-05-01)

Enzymatic Activity of CD73 Modulates Invasion of Gliomas via Epithelial–Mesenchymal Transition-Like Reprogramming
by: Julia Tsiampali, et al.
Published: (2020-11-01)

Frequency of circulating CD8+CD73+T cells is associated with survival in nivolumab-treated melanoma patients
by: Mariaelena Capone, et al.
Published: (2020-03-01)

Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization
by: M. Samiul Alam, et al.
Published: (2015-05-01)

Landscape of adenosine pathway and immune checkpoint dual blockade in NSCLC: progress in basic research and clinical application
by: Rulan Wang, et al.
Published: (2024-01-01)

A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape
by: Markus Kellner, et al.
Published: (2022-03-01)

ATP, an extracellular signaling molecule in red blood cells: A messenger for malaria?
by: Ghania Ramdani, et al.
Published: (2014-10-01)