Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3

Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3

Chronic pulmonary inflammation and chronic obstructive pulmonary disease (COPD) are major health issues largely due to air pollution and cigarette smoke (CS) exposure. The role of the innate receptor NLRP3 (nucleotide-binding domain and leucine-rich repeat containing protein 3) orchestrating inflamm...

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Bibliographic Details
Main Authors: Sarah Huot-Marchand, Mégane Nascimento, Elodie Culerier, Mélissa Bourenane, Florence Savigny, Corinne Panek, Cindy Serdjebi, Marc Le Bert, Valérie F. J. Quesniaux, Bernhard Ryffel, Petr Broz, Nicolas Riteau, Aurélie Gombault, Isabelle Couillin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
cigarette smoke
NLRP3 inflammasome
gasdermin D
lung
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.918507/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.918507/full

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