Surface Display of Peptides Corresponding to the Heptad Repeat 2 Domain of the Feline Enteric Coronavirus Spike Protein on Bacillus subtilis Spores Elicits Protective Immune Responses Against Homologous Infection in a Feline Aminopeptidase-N-Transduced Mouse Model

Surface Display of Peptides Corresponding to the Heptad Repeat 2 Domain of the Feline Enteric Coronavirus Spike Protein on Bacillus subtilis Spores Elicits Protective Immune Responses Against Homologous Infection in a Feline Aminopeptidase-N-Transduced Mouse Model

Although feline coronavirus (FCoV) infection is extremely common in cats, there are currently few effective treatments. A peptide derived from the heptad repeat 2 (HR2) domain of the coronavirus (CoV) spike protein has shown effective for inhibition of various human and animal CoVs in vitro, but fur...

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Bibliographic Details
Main Authors: Chu Chen, Ya-Li Li, Fang-Li Lv, Ling-Dong Xu, Yao-Wei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
feline coronavirus (FCoV)
heptad repeat 2 (HR2)
Bacillus subtilis
mouse model
recombinant oral vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.925922/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.925922/full

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