Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases

Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases

Mucolipins (TRPML) are endosome/lysosome Ca2+ permeable channels belonging to the family of transient receptor potential channels. In mammals, there are three TRPML proteins, TRPML1, 2, and 3, encoded by MCOLN1-3 genes. Among these channels, TRPML1 is a reactive oxygen species sensor localized on th...

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Bibliographic Details
Main Authors: Giorgio Santoni, Federica Maggi, Consuelo Amantini, Oliviero Marinelli, Massimo Nabissi, Maria Beatrice Morelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
neurodegenerative disease
TRPML1
lysosomal storage disease
oxidative stress
mitochondria
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00251/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00251/full

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