iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse

iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse

Abstract Toxoplasma gondii is an obligate intracellular parasite of rodents and humans. Interferon-inducible guanylate binding proteins (GBPs) are mediators of T. gondii clearance, however, this mechanism is incomplete. Here, using automated spatially targeted optical micro proteomics we demonstrate...

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Bibliographic Details
Main Authors: Xiao-Yu Zhao, Samantha L. Lempke, Jan C. Urbán Arroyo, Isabel G. Brown, Bocheng Yin, Magdalena M. Magaj, Nadia K. Holness, Jamison Smiley, Stefanie Redemann, Sarah E. Ewald
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46790-y

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https://doi.org/10.1038/s41467-024-46790-y

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