Amphotericin B resistance correlates with increased fitness in vitro and in vivo in Leishmania (Mundinia) martiniquensis

Amphotericin B resistance correlates with increased fitness in vitro and in vivo in Leishmania (Mundinia) martiniquensis

Amphotericin B (AmpB) deoxycholate is the available first-line drug used to treat visceral leishmaniasis caused by Leishmania (Mundinia) martiniquensis, however, some cases of AmpB treatment failure have been reported in Thailand. Resistance to drugs is known to affect parasite fitness with a potent...

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Bibliographic Details
Main Authors: Chonlada Mano, Aphisek Kongkaew, Pongsri Tippawangkosol, Pradya Somboon, Sittiruk Roytrakul, Pascale Pescher, Gerald F. Späth, Chairat Uthaipibull, Adisak Tantiworawit, Padet Siriyasatien, Narissara Jariyapan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Microbiology
Subjects:
Leishmania
Leishmania martiniquensis
leishmaniasis
fitness
Amphotericin B
drug resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1156061/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1156061/full

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