Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase

Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase

KIAA1199 has a strong hyaluronidase activity in inflammatory arthritis. This study aimed to identify a drug that could reduce KIAA1199 activity and clarify its effects on inflammatory arthritis. Rat chondrosarcoma (RCS) cells were strongly stained with Alcian blue (AB). Its stainability was reduced...

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Bibliographic Details
Main Authors: Hiroshi Koike, Yoshihiro Nishida, Tamayuki Shinomura, Bisei Ohkawara, Kinji Ohno, Lisheng Zhuo, Koji Kimata, Takahiro Ushida, Shiro Imagama
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
KIAA1199
inflammatory arthritis
hyaluronan
hyaluronidase
collagen-induced arthritis
CEMIP
Online Access:https://www.mdpi.com/1422-0067/23/8/4089

Internet

https://www.mdpi.com/1422-0067/23/8/4089

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