Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism

Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism

Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skeletal muscle fibers; this calcium increase woul...

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Bibliographic Details
Main Authors: Alexis R. Díaz-Vegas, Alex Cordova, Denisse Valladares, Paola Llanos, Cecilia Hidalgo, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Rosario Rizzuto, Ariel Contreras-Ferrat, Enrique Jaimovich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
energy distribution
inositol 1,4,5-trisphosphate receptor
mitochondria heterogeneity
mitochondrial network
ryanodine receptors
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00791/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00791/full

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