Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model

Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model

Abstract Impaired gut homeostasis is associated with stroke often presenting with leaky gut syndrome and increased gut, brain, and systemic inflammation that further exacerbates brain damage. We previously reported that intracisternal administration of Tanshinone IIA-loaded nanoparticles (Tan IIA-NP...

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Bibliographic Details
Main Authors: Julie H. Jeon, Erin E. Kaiser, Elizabeth S. Waters, Xueyuan Yang, Jeferson M. Lourenco, Madison M. Fagan, Kelly M. Scheulin, Sydney E. Sneed, Soo K. Shin, Holly A. Kinder, Anil Kumar, Simon R. Platt, Jeongyoun Ahn, Kylee J. Duberstein, Michael J. Rothrock, Todd R. Callaway, Jin Xie, Franklin D. West, Hea Jin Park
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-29282-9

Internet

https://doi.org/10.1038/s41598-023-29282-9

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