Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion

Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion

Objective: IL-6 is an important contributor to glucose and energy homeostasis through changes in whole-body glucose disposal, insulin sensitivity, food intake and energy expenditure. However, the relative contributions of peripheral versus central IL-6 signaling to these metabolic actions are presen...

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Bibliographic Details
Main Authors: Alison D. McNeilly, Adonis Yianakas, Jennifer G. Gallagher, Jamie Tarlton, Michael LJ. Ashford, Rory J. McCrimmon
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Molecular Metabolism
Subjects:
Interleukin-6
Food intake
Energy expenditure
Insulin secretion
Autonomic output
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000576

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http://www.sciencedirect.com/science/article/pii/S2212877822000576

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