A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia—Relevance for Preeclampsia Therapy

A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia—Relevance for Preeclampsia Therapy

Background: Preeclampsia (PE) is a severe, life-threatening complication during pregnancy (~5–7%), and no causative treatment is available. Early aberrant spiral artery remodeling is associated with placental stress and the release of oxygen radicals and other reactive oxygen species (ROS) in the pl...

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Bibliographic Details
Main Authors: Diana Pintye, Réka E. Sziva, Maxim Mastyugin, Brett C. Young, Sonako Jacas, Marianna Török, Saira Salahuddin, Prakash Jagtap, Garry J. Southan, Zsuzsanna K. Zsengellér
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biology
Subjects:
preeclampsia
nitric oxide-donor
redox modulator
SOD mimetic
placental villous explant
hypoxia
Online Access:https://www.mdpi.com/2079-7737/12/9/1229

Internet

https://www.mdpi.com/2079-7737/12/9/1229

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