An IGF-1R-mTORC1-SRPK2 signaling Axis contributes to FASN regulation in breast cancer

An IGF-1R-mTORC1-SRPK2 signaling Axis contributes to FASN regulation in breast cancer

Abstract Background Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor tyrosine kinase (RTK) signaling pathways. Recently, post transcriptional regulation of lipogenic transcripts have been demonstrated as being...

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Bibliographic Details
Main Authors: Bryan McClellan, Paul Gries, Brittany Harlow, Stefano Tiziani, Christopher Jolly, Linda deGraffenried
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Cancer
Subjects:
RTK signaling
RNA metabolism
Cancer metabolism
Breast Cancer
Fatty acid synthase
Online Access:https://doi.org/10.1186/s12885-022-10062-z

Internet

https://doi.org/10.1186/s12885-022-10062-z

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