Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia
Schizophrenia is a mental disorder that is characterized by various abnormal symptoms. Previous studies indicate decreased expression of Phospholipase C-β1 (PLC-β1) in the brains of patients with schizophrenia. PLC-β1-null (PLC-β1-/-) mice exhibit multiple endophenotypes of schizophrenia. Furthermor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00159/full |
| _version_ | 1818519481785253888 |
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| author | Seong-Wook eKim Taesup eCho Sukchan eLee |
| author_facet | Seong-Wook eKim Taesup eCho Sukchan eLee |
| author_sort | Seong-Wook eKim |
| collection | DOAJ |
| description | Schizophrenia is a mental disorder that is characterized by various abnormal symptoms. Previous studies indicate decreased expression of Phospholipase C-β1 (PLC-β1) in the brains of patients with schizophrenia. PLC-β1-null (PLC-β1-/-) mice exhibit multiple endophenotypes of schizophrenia. Furthermore, a study of PLC-β1 knockdown in the medial prefrontal cortex (mPFC) of mice has shown a specific behavioral deficit, impaired working memory. These results support the notion that disruption of PLC-β1-linked signaling in the brain is strongly involved in the pathogenesis of schizophrenia. In this review, we broadly investigate recent studies regarding schizophrenia-related behaviors as well as their various clinical and biological correlates in PLC-β1-/- and knockdown mouse models. This will provide a better understanding of the pathological relevance of the altered expression of PLC-β1 in the brains of patients with schizophrenia. Evidence accumulated will shed light on future in-depth studies, possibly in human subjects. |
| first_indexed | 2024-12-11T01:24:47Z |
| format | Article |
| id | doaj.art-6d5060e3af0a4b4e892a44a17e68b327 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T01:24:47Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-6d5060e3af0a4b4e892a44a17e68b3272022-12-22T01:25:35ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402015-11-01610.3389/fpsyt.2015.00159166655Phospholipase C-β1 hypofunction in the pathogenesis of schizophreniaSeong-Wook eKim0Taesup eCho1Sukchan eLee2Center for Cognition and Sociality, Institute for Basic Science (IBS), E18-3, 291 Daehak-ro, Yuseong-gu, Daejeon, 305-338 Republic of KoreaCenter for Cognition and Sociality, Institute for Basic Science (IBS), E18-3, 291 Daehak-ro, Yuseong-gu, Daejeon, 305-338 Republic of KoreaBehavioral Genetics Lab, Dept.of Biological Science, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehang-no, Daejeon, Republic of KoreaSchizophrenia is a mental disorder that is characterized by various abnormal symptoms. Previous studies indicate decreased expression of Phospholipase C-β1 (PLC-β1) in the brains of patients with schizophrenia. PLC-β1-null (PLC-β1-/-) mice exhibit multiple endophenotypes of schizophrenia. Furthermore, a study of PLC-β1 knockdown in the medial prefrontal cortex (mPFC) of mice has shown a specific behavioral deficit, impaired working memory. These results support the notion that disruption of PLC-β1-linked signaling in the brain is strongly involved in the pathogenesis of schizophrenia. In this review, we broadly investigate recent studies regarding schizophrenia-related behaviors as well as their various clinical and biological correlates in PLC-β1-/- and knockdown mouse models. This will provide a better understanding of the pathological relevance of the altered expression of PLC-β1 in the brains of patients with schizophrenia. Evidence accumulated will shed light on future in-depth studies, possibly in human subjects.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00159/fullSchizophreniaDLPFCmPFCPLC-β1Schizophrenia endophenotypes |
| spellingShingle | Seong-Wook eKim Taesup eCho Sukchan eLee Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia Frontiers in Psychiatry Schizophrenia DLPFC mPFC PLC-β1 Schizophrenia endophenotypes |
| title | Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia |
| title_full | Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia |
| title_fullStr | Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia |
| title_full_unstemmed | Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia |
| title_short | Phospholipase C-β1 hypofunction in the pathogenesis of schizophrenia |
| title_sort | phospholipase c β1 hypofunction in the pathogenesis of schizophrenia |
| topic | Schizophrenia DLPFC mPFC PLC-β1 Schizophrenia endophenotypes |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00159/full |
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