Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast

Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast

Di (2-ethyl-hexyl) phthalate (DEHP) is a wildly used plasticizer. Maternal exposure to DEHP during pregnancy blocks the placental cell cycle at the G2/M phase by reducing the efficiency of the DNA repair pathways and affects the health of offsprings. However, the mechanism by which DEHP inhibits the...

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Bibliographic Details
Main Authors: Shuai Zhao, Yun Hong, Yue-yue Liang, Xiao-lu Li, Jiang-chuan Shen, Cong-cong Sun, Ling-luo Chu, Jie Hu, Hua Wang, De-xiang Xu, Shi-chen Zhang, Dou-dou Xu, Tao Xu, Ling-li Zhao
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
Di (2-ethyl-hexyl) phthalate
Nicotinamide adenine dinucleotide
ATP
DNA damage
Placental development
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001860

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http://www.sciencedirect.com/science/article/pii/S2213231722001860

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