Modeling of the Aqueous Solubility of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a] pyrazine-3-carboxamide: From Micronization to Creation of Amorphous–Crystalline Composites with a Polymer

Modeling of the Aqueous Solubility of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a] pyrazine-3-carboxamide: From Micronization to Creation of Amorphous–Crystalline Composites with a Polymer

N-butyl-N-methyl-1-phenylpyrrole[1,2-a] pyrazine-3-carboxamide (GML-3) is a potential candidate for combination drug therapy due to its anxiolytic and antidepressant activity. The anxiolytic activity of GML-3 is comparable to diazepam. The antidepressant activity of GML-3 is comparable to amitriptyl...

Full description

Bibliographic Details
Main Authors: Vladimir B. Markeev, Sergey V. Tishkov, Anton M. Vorobei, Olga O. Parenago, Evgenia V. Blynskaya, Konstantin V. Alekseev, Anna I. Marakhova, Alexandre A. Vetcher
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Polymers
Subjects:
polymorphism
micronization
solubility
polyvinylpyrrolidone
anxiolytics
antidepressants
Online Access:https://www.mdpi.com/2073-4360/15/20/4136

Internet

https://www.mdpi.com/2073-4360/15/20/4136

Similar Items