In Vitro α-Glucosidase and α-Amylase Inhibition, Cytotoxicity and Free Radical Scavenging Profiling of the 6-Halogeno and Mixed 6,8-Dihalogenated 2-Aryl-4-methyl-1,2-dihydroquinazoline 3-Oxides

In Vitro α-Glucosidase and α-Amylase Inhibition, Cytotoxicity and Free Radical Scavenging Profiling of the 6-Halogeno and Mixed 6,8-Dihalogenated 2-Aryl-4-methyl-1,2-dihydroquinazoline 3-Oxides

Series of the 6-bromo/iodo substituted 2-aryl-4-methyl-1,2-dihydroquinazoline-3-oxides and their mixed 6,8-dihalogenated (Br/I and I/Br) derivatives were evaluated for inhibitory properties against α-glucosidase and/or α-amylase activities and for cytotoxicity against breast (MCF-7) and lung (A549)...

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Bibliographic Details
Main Authors: Nontokozo M. Magwaza, Garland K. More, Samantha Gildenhuys, Malose J. Mphahlele
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Antioxidants
Subjects:
halogenated 1,2-dihydroquinazoline 3-oxides
diabetes
cytotoxicity
antioxidant activity
molecular docking
Online Access:https://www.mdpi.com/2076-3921/12/11/1971

Internet

https://www.mdpi.com/2076-3921/12/11/1971

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