Disrupting enzyme fluidity
A combination of X-ray crystallography, NMR, and mass spectrometry has revealed how diverse small-molecule inhibitors bind Bruton’s tyrosine kinase and alter the conformation of this enzyme.
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/65221 |
| _version_ | 1797997561090408448 |
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| author | Ganesh Srinivasan Anand |
| author_facet | Ganesh Srinivasan Anand |
| author_sort | Ganesh Srinivasan Anand |
| collection | DOAJ |
| description | A combination of X-ray crystallography, NMR, and mass spectrometry has revealed how diverse small-molecule inhibitors bind Bruton’s tyrosine kinase and alter the conformation of this enzyme. |
| first_indexed | 2024-04-11T10:34:36Z |
| format | Article |
| id | doaj.art-6d5b7c8f5baf46aea5ae0b6d3a9aad0b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:34:36Z |
| publishDate | 2021-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-6d5b7c8f5baf46aea5ae0b6d3a9aad0b2022-12-22T04:29:19ZengeLife Sciences Publications LtdeLife2050-084X2021-01-011010.7554/eLife.65221Disrupting enzyme fluidityGanesh Srinivasan Anand0https://orcid.org/0000-0001-8995-3067Department of Chemistry and Huck Institute of Life Sciences, Pennsylvania State University, University Park, United StatesA combination of X-ray crystallography, NMR, and mass spectrometry has revealed how diverse small-molecule inhibitors bind Bruton’s tyrosine kinase and alter the conformation of this enzyme.https://elifesciences.org/articles/65221bruton tyrosine kinasekinase inhibitordrug resistanceallosteryhydrogen/deuterium exchange mass spectrometrynuclear magnetic resonance |
| spellingShingle | Ganesh Srinivasan Anand Disrupting enzyme fluidity eLife bruton tyrosine kinase kinase inhibitor drug resistance allostery hydrogen/deuterium exchange mass spectrometry nuclear magnetic resonance |
| title | Disrupting enzyme fluidity |
| title_full | Disrupting enzyme fluidity |
| title_fullStr | Disrupting enzyme fluidity |
| title_full_unstemmed | Disrupting enzyme fluidity |
| title_short | Disrupting enzyme fluidity |
| title_sort | disrupting enzyme fluidity |
| topic | bruton tyrosine kinase kinase inhibitor drug resistance allostery hydrogen/deuterium exchange mass spectrometry nuclear magnetic resonance |
| url | https://elifesciences.org/articles/65221 |
| work_keys_str_mv | AT ganeshsrinivasananand disruptingenzymefluidity |