A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition

A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition

Epithelial ovarian cancer is the most lethal malignancy of the female reproductive tract. A healthy ovary expresses both Estrogen Receptor α (ERα) and β (ERβ). Given that ERα is generally considered to promote cell survival and proliferation, thereby, enhancing tumor growth, while ERβ shows a protec...

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Bibliographic Details
Main Authors: Ananya Banerjee, Shurui Cai, Guozhen Xie, Na Li, Xuetao Bai, Kousalya Lavudi, Kevin Wang, Xiaoli Zhang, Junran Zhang, Srinivas Patnaik, Floor J. Backes, Chad Bennett, Qi-En Wang
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
Estrogen receptor
cancer stem cells
epithelial-to-mesenchymal transition
ovarian cancer
Online Access:https://www.mdpi.com/2072-6694/14/9/2311

Internet

https://www.mdpi.com/2072-6694/14/9/2311

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