Blocking LAIR1 signaling in immune cells inhibits tumor development

Blocking LAIR1 signaling in immune cells inhibits tumor development

The current immune checkpoint blockade therapy has been successful in treating some cancers but not others. New molecular targets and therapeutic approaches of cancer immunology need to be identified. Leukocyte associated immunoglobulin like receptor 1 (LAIR1) is an immune inhibitory receptor expres...

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Bibliographic Details
Main Authors: Jingjing Xie, Xun Gui, Mi Deng, Heyu Chen, Yuanzhi Chen, Xiaoye Liu, Zhiqiang Ku, Lingxiao Tan, Ryan Huang, Yubo He, Bruce Zhang, Cheryl Lewis, Kenian Chen, Lin Xu, Jian Xu, Tao Huang, X. Charlene Liao, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
antibody
cancer immunotherapy
RNAseq
T cell
myeloid cells
natural killer cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.996026/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.996026/full

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