CRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits

CRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits

Abstract Background High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. We aim to create APOC3-knockout (KO) rabbits and explore the effects of APOC3 deletion on the occurrence and development of atherosclerosis. Methods An s...

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Bibliographic Details
Main Authors: Yiwen Zha, Yaoyao Lu, Ting Zhang, Kunning Yan, Wenwen Zhuang, Jingyan Liang, Yong Cheng, Yingge Wang
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Lipids in Health and Disease
Subjects:
Apolipoprotein
Triglycerides
Atherosclerosis
CRISPR/Cas9
Rabbit
Online Access:https://doi.org/10.1186/s12944-021-01605-7

Internet

https://doi.org/10.1186/s12944-021-01605-7

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