Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining

Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining

In neonatal jaundice, high levels of unconjugated bilirubin (UCB) may induce neurological dysfunction (BIND). Recently, it was observed that UCB induces alterations on brain microvasculature, which may facilitate its entrance into the brain, but little is known about the steps involved. To evaluate...

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Bibliographic Details
Main Authors: Inês ePalmela, Hiroyuki eSasaki, Filipa Lourenço Cardoso, Kwang Sik Kim, Dora eBrites, Maria A Brito
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Blood-Brain Barrier
Caveolae
Endothelial Cells
Intercellular Junctions
Integrity
Unconjugated bilirubin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00022/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00022/full

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