Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila

Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila

Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery. Yet, how defects in splicing factor genes are linked to the aetiology of the...

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Bibliographic Details
Main Authors: Sarita Hebbar, Malte Lehmann, Sarah Behrens, Catrin Hälsig, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust
Format: Article
Language:English
Published: The Company of Biologists 2021-01-01
Series:Biology Open
Subjects:
spliceosome
photoreceptor cells
rhodopsin
scarlet
twinfilin
Online Access:http://bio.biologists.org/content/10/1/bio052332

Internet

http://bio.biologists.org/content/10/1/bio052332

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