Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant <i>Pseudomonas aeruginosa</i> and Minimize Biofilm Formation

Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant <i>Pseudomonas aeruginosa</i> and Minimize Biofilm Formation

The emergence of antibiotic resistance has severely impaired the treatment of chronic respiratory infections caused by multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i>. Since the reintroduction of polymyxins as a last-line therapy against MDR Gram-negative bacteria, resistance to...

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Bibliographic Details
Main Authors: Hasini Wickremasinghe, Heidi H. Yu, Mohammad A. K. Azad, Jinxin Zhao, Phillip J. Bergen, Tony Velkov, Qi Tony Zhou, Yan Zhu, Jian Li
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antibiotics
Subjects:
polymyxin
meropenem
combination therapy
multidrug resistance
<i>Pseudomonas aeruginosa</i>
synergy
Online Access:https://www.mdpi.com/2079-6382/10/4/405

Internet

https://www.mdpi.com/2079-6382/10/4/405

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