A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

Munson et al. develop a high-throughput Galectin-9 reporter based endosomal escape imaging assay to probe correlations between nanoparticle-mediated uptake, endosomal escape frequency, and mRNA translation. By screening various delivery systems, modulators and combinations of nanoparticle components...

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Bibliographic Details
Main Authors: Michael J. Munson, Gwen O’Driscoll, Andreia M. Silva, Elisa Lázaro-Ibáñez, Audrey Gallud, John T. Wilson, Anna Collén, Elin K. Esbjörner, Alan Sabirsh
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01728-8

Internet

https://doi.org/10.1038/s42003-021-01728-8

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