A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

Mutations in the non-coding RNA RMRP cause primary immunodeficiency. Robertson et al show that a disease-associated mutation in RMRP impairs pre-ribosomal RNA processing and reduces ribosome abundance, establishing this disorder as a ribosomopathy.

Bibliographic Details
Main Authors: Nic Robertson, Vadim Shchepachev, David Wright, Tomasz W. Turowski, Christos Spanos, Aleksandra Helwak, Rose Zamoyska, David Tollervey
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28295-8

Internet

https://doi.org/10.1038/s41467-022-28295-8

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