Ferroptosis: A potential target for the intervention of intervertebral disc degeneration
Ferroptosis, an iron-dependent form of programmed cell death marked by phospholipid peroxidation, is regulated by complex cellular metabolic pathways including lipid metabolism, iron balance, redox homeostasis, and mitochondrial activity. Initial research regarding the mechanism of ferroptosis mainl...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1042060/full |
| _version_ | 1797985764661788672 |
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| author | Lu-Ping Zhou Ren-Jie Zhang Chong-Yu Jia Liang Kang Zhi-Gang Zhang Hua-Qing Zhang Jia-Qi Wang Bo Zhang Cai-Liang Shen |
| author_facet | Lu-Ping Zhou Ren-Jie Zhang Chong-Yu Jia Liang Kang Zhi-Gang Zhang Hua-Qing Zhang Jia-Qi Wang Bo Zhang Cai-Liang Shen |
| author_sort | Lu-Ping Zhou |
| collection | DOAJ |
| description | Ferroptosis, an iron-dependent form of programmed cell death marked by phospholipid peroxidation, is regulated by complex cellular metabolic pathways including lipid metabolism, iron balance, redox homeostasis, and mitochondrial activity. Initial research regarding the mechanism of ferroptosis mainly focused on the solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (GPX4) signal pathway. Recently, novel mechanisms of ferroptosis, independent of GPX4, have been discovered. Numerous pathologies associated with extensive lipid peroxidation, such as drug-resistant cancers, ischemic organ injuries, and neurodegenerative diseases, are driven by ferroptosis. Ferroptosis is a new therapeutic target for the intervention of IVDD. The role of ferroptosis in the modulation of intervertebral disc degeneration (IVDD) is a significant topic of interest. This is a novel research topic, and research on the mechanisms of IVDD and ferroptosis is ongoing. Herein, we aim to review and discuss the literature to explore the mechanisms of ferroptosis, the relationship between IVDD and ferroptosis, and the regulatory networks in the cells of the nucleus pulposus, annulus fibrosus, and cartilage endplate to provide references for future basic research and clinical translation for IVDD treatment. |
| first_indexed | 2024-04-11T07:23:12Z |
| format | Article |
| id | doaj.art-6d76ba3f23e24b929038a283f0b66c8a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T07:23:12Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6d76ba3f23e24b929038a283f0b66c8a2022-12-22T04:37:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.10420601042060Ferroptosis: A potential target for the intervention of intervertebral disc degenerationLu-Ping ZhouRen-Jie ZhangChong-Yu JiaLiang KangZhi-Gang ZhangHua-Qing ZhangJia-Qi WangBo ZhangCai-Liang ShenFerroptosis, an iron-dependent form of programmed cell death marked by phospholipid peroxidation, is regulated by complex cellular metabolic pathways including lipid metabolism, iron balance, redox homeostasis, and mitochondrial activity. Initial research regarding the mechanism of ferroptosis mainly focused on the solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (GPX4) signal pathway. Recently, novel mechanisms of ferroptosis, independent of GPX4, have been discovered. Numerous pathologies associated with extensive lipid peroxidation, such as drug-resistant cancers, ischemic organ injuries, and neurodegenerative diseases, are driven by ferroptosis. Ferroptosis is a new therapeutic target for the intervention of IVDD. The role of ferroptosis in the modulation of intervertebral disc degeneration (IVDD) is a significant topic of interest. This is a novel research topic, and research on the mechanisms of IVDD and ferroptosis is ongoing. Herein, we aim to review and discuss the literature to explore the mechanisms of ferroptosis, the relationship between IVDD and ferroptosis, and the regulatory networks in the cells of the nucleus pulposus, annulus fibrosus, and cartilage endplate to provide references for future basic research and clinical translation for IVDD treatment.https://www.frontiersin.org/articles/10.3389/fendo.2022.1042060/fullferroptosisintervertebral disc degenerationironlipid peroxidationtherapeutic implication |
| spellingShingle | Lu-Ping Zhou Ren-Jie Zhang Chong-Yu Jia Liang Kang Zhi-Gang Zhang Hua-Qing Zhang Jia-Qi Wang Bo Zhang Cai-Liang Shen Ferroptosis: A potential target for the intervention of intervertebral disc degeneration Frontiers in Endocrinology ferroptosis intervertebral disc degeneration iron lipid peroxidation therapeutic implication |
| title | Ferroptosis: A potential target for the intervention of intervertebral disc degeneration |
| title_full | Ferroptosis: A potential target for the intervention of intervertebral disc degeneration |
| title_fullStr | Ferroptosis: A potential target for the intervention of intervertebral disc degeneration |
| title_full_unstemmed | Ferroptosis: A potential target for the intervention of intervertebral disc degeneration |
| title_short | Ferroptosis: A potential target for the intervention of intervertebral disc degeneration |
| title_sort | ferroptosis a potential target for the intervention of intervertebral disc degeneration |
| topic | ferroptosis intervertebral disc degeneration iron lipid peroxidation therapeutic implication |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1042060/full |
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