Time-dependent biochemical effects of the promising anticancer drug 3-bromopyruvate and its biochemical analogs pyruvate and lactate (Warburg effect) on C6 glioma-induced H2O2 production
Background: Pyruvate (an antioxidant) result from aerobic glucose oxidation (aerobic glycolysis) while lactate (a pro-oxidant metabolite in the tumor microenvironment) results from anaerobic glycolysis. Lactate is a structural analog to pyruvate (formed in anaerobic conditions via adding two hydroge...
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2024-07-01
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| Series: | SVU - International Journal of Medical Sciences |
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| Online Access: | https://svuijm.journals.ekb.eg/article_362450.html |