PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis

PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis

Abstract Background Osteoarthritis (OA) is a prevalent disease plaguing the elderly. Recently, chondrocyte ferroptosis has been demonstrated to promote the progression of OA. Peroxisome proliferator-activated receptor-γ (PPARγ) is an important factor in maintaining cartilage health. However, the rel...

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Bibliographic Details
Main Authors: Xiang Xue, Tianming Dai, Junyan Chen, Yangyang Xu, Zhenyu Yang, Jian Huang, Wuyan Xu, Siming Li, Qingqi Meng
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoarthritis
Chondrocyte
PPARγ
Ferroptosis
Pink1
Mitophagy
Online Access:https://doi.org/10.1186/s13018-023-04092-x

Internet

https://doi.org/10.1186/s13018-023-04092-x

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