The role of iron in anthracycline cardiotoxicity

The role of iron in anthracycline cardiotoxicity

The clinical use of the antitumor anthracycline Doxorubicin is limited by the risk of severe cardiotoxicity. The mechanisms underlying anthracycline-dependent cardiotoxicity are multiple and remain uncompletely understood, but many observations indicate that interactions with cellular iron metabolis...

Full description

Bibliographic Details
Main Authors: Elena eGammella, Federica eMaccarinelli, Paolo eBuratti, Stefania eRecalcati, Gaetano eCairo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Pharmacology
Subjects:
Anthracyclines
Doxorubicin
Heart
Iron
Reactive Oxygen Species
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00025/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00025/full

Similar Items