Hsp47 Inhibitor Col003 Attenuates Collagen-Induced Platelet Activation and Cerebral Ischemic–Reperfusion Injury in Rats

Hsp47 Inhibitor Col003 Attenuates Collagen-Induced Platelet Activation and Cerebral Ischemic–Reperfusion Injury in Rats

Ischemic stroke is a major type of stroke worldwide currently without effective treatment, although antiplatelet therapy is an existing option for it. In previous studies, heat shock protein 47 (Hsp47) was found to be expressed on the surface of human and mice platelets and to strengthen the interac...

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Bibliographic Details
Main Authors: Shuang Wu, Chengwei Liang, Xiaoyun Xie, Haiping Huang, Jinfeng Fu, Cilan Wang, Zhiheng Su, Youqiong Wang, Xiang Qu, Jinpin Li, Jingli Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
ischemic stroke
antiplatelet
Col003
HSP47
GPVI
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.792263/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.792263/full

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