Network pharmacology-based investigation and experimental validation of the mechanism of scutellarin in the treatment of acute myeloid leukemia

Network pharmacology-based investigation and experimental validation of the mechanism of scutellarin in the treatment of acute myeloid leukemia

Background: It has been demonstrated that scutellarin, a natural flavone compound from Scutellaria lateriflora and Scutellaria barbata, exerts selective cytotoxicity against a range of cancer cells. However, the underlining mechanism of scutellarin on acute myeloid leukemia (AML) remains elusive.Met...

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Bibliographic Details
Main Authors: Zhe Huang, Yan Yang, Xianming Fan, Wenzhe Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Scutellarin
AML
network pharmacology
JNK/Caspase-3 signal pathway
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.952677/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.952677/full

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