An Equivocal Final Link – Quantitative Determination of the Thermodynamic Efficiency of ATP Hydrolysis – Sullies the Chain of Electric, Ionic, Mechanical and Metabolic Steps Underlying Cardiac Contraction

An Equivocal Final Link – Quantitative Determination of the Thermodynamic Efficiency of ATP Hydrolysis – Sullies the Chain of Electric, Ionic, Mechanical and Metabolic Steps Underlying Cardiac Contraction

Each beat of the heart completes the final step in a sequence of events commencing with electrical excitation-triggered release of Ca2+ from the sarcoplasmic reticulum which, in turn, triggers ATP-hydrolysis-dependent mechanical contraction. Given that Thermodynamics is inherently detail-independent...

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Bibliographic Details
Main Authors: Christopher John Barclay, Denis Scott Loiselle
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
thermodynamics
cardiac muscle
metabolism
myothermia
stoichiometry of mitochondrial ATP production
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00183/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00183/full

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