BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ

RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signalling in humans. Here, we report a novel function of the breast cancer 1 (BRCA1)-BRCA1-associated ring domain 1 (...

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Bibliographic Details
Main Authors: Heeyoun Bunch, Jaehyeon Jeong, Keunsoo Kang, Doo Sin Jo, Anh T. Q. Cong, Deukyeong Kim, Donguk Kim, Dong-Hyung Cho, You Mie Lee, Benjamin P. C. Chen, Matthew J. Schellenberg, Stuart K. Calderwood
Format: Article
Language:English
Published: The Royal Society 2021-10-01
Series:Open Biology
Subjects:
BRCA1-BARD1 complex
topoisomerase IIβ
transcription-coupled DNA break
gene regulation
stimulus-inducible transcriptional activation
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210221

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.210221

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