BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ

RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signalling in humans. Here, we report a novel function of the breast cancer 1 (BRCA1)-BRCA1-associated ring domain 1 (...

Full description

Bibliographic Details
Main Authors:	Heeyoun Bunch, Jaehyeon Jeong, Keunsoo Kang, Doo Sin Jo, Anh T. Q. Cong, Deukyeong Kim, Donguk Kim, Dong-Hyung Cho, You Mie Lee, Benjamin P. C. Chen, Matthew J. Schellenberg, Stuart K. Calderwood
Format:	Article
Language:	English
Published:	The Royal Society 2021-10-01
Series:	Open Biology
Subjects:	BRCA1-BARD1 complex topoisomerase IIβ transcription-coupled DNA break gene regulation stimulus-inducible transcriptional activation
Online Access:	https://royalsocietypublishing.org/doi/10.1098/rsob.210221

Similar Items

BRCA1-BARD1: the importance of being in shape
by: Manuel Daza-Martin, et al.
Published: (2019-11-01)

The Function of BARD1 in Centrosome Regulation in Cooperation with BRCA1/OLA1/RACK1
by: Kei Otsuka, et al.
Published: (2020-07-01)

BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis
by: Qianyan Li, et al.
Published: (2021-04-01)

Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy
by: Xin Yue, et al.
Published: (2023-08-01)

Expression of BARD1 β Isoform in Selected Pediatric Tumors
by: Anna Jasiak, et al.
Published: (2021-01-01)

BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility
by: Wen Fu, et al.
Published: (2017-02-01)

The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers
by: Andrea K. Watters, et al.
Published: (2020-07-01)

RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor
by: Hella A. Bolck, et al.
Published: (2022-02-01)

Topoisomerase I in Human Disease Pathogenesis and Treatments
by: Min Li, et al.
Published: (2016-06-01)

BARD1 Autoantibody Blood Test for Early Detection of Ovarian Cancer
by: Maxim Pilyugin, et al.
Published: (2021-06-01)

DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence
by: María José Lista, et al.
Published: (2023-05-01)

Functional analysis of clinical BARD1 germline variants
by: Toh, Ming Ren, et al.
Published: (2020)

BARD1 mystery: tumor suppressors are cancer susceptibility genes
by: Yousef M. Hawsawi, et al.
Published: (2022-06-01)

Renovation and development of the «Fortress of Bard» monument complex
by: Giuseppe Cacozza
Published: (2012-04-01)

Women’s contribution in understanding how topoisomerases, supercoiling, and transcription control genome organization
by: Laura Martin, et al.
Published: (2023-03-01)

BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression
by: Xiaowen Zhang, et al.
Published: (2018-12-01)

The Yorùbá Royal Bards
by: Akintunde Akinyemi
Published: (2001-12-01)

Differential Expression of <i>BARD1</i> Isoforms in Melanoma
by: Lorissa I. McDougall, et al.
Published: (2021-02-01)

Topoisomerase 2β and DNA topology during B cell development
by: Olivier Papapietro, et al.
Published: (2022-08-01)

The Roles of DNA Topoisomerase IIβ in Transcription
by: Ram Madabhushi
Published: (2018-06-01)

Do BARD1 Mutations Confer an Elevated Risk of Prostate Cancer?
by: Klaudia Stempa, et al.
Published: (2021-10-01)

Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds
by: Josephine Geertsen Keller, et al.
Published: (2023-04-01)

BRCA1: An Endocrine and Metabolic Regulator
by: Haim Werner
Published: (2022-03-01)

HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms
by: Aditi Jain, et al.
Published: (2022-04-01)

Topoisomerase I prevents transcription-replication conflicts at transcription termination sites
by: Yaqun Liu, et al.
Published: (2021-01-01)

<i>BARD1</i> and Breast Cancer: The Possibility of Creating Screening Tests and New Preventive and Therapeutic Pathways for Predisposed Women
by: Marcin Śniadecki, et al.
Published: (2020-10-01)

Prostate screening uptake in Australian <it>BRCA1 </it>and <it>BRCA2 </it>carriers
by: McKinley Joanne M, et al.
Published: (2007-09-01)

DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
by: Fernando Gómez-Herreros, et al.
Published: (2019-12-01)

Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer
by: Nana Weber-Lassalle, et al.
Published: (2019-04-01)

Male with an apparently normal phenotype carrying a BRCA1 exon 20 duplication in trans to a BRCA1 frameshift variant
by: Ines Block, et al.
Published: (2024-01-01)

Prostate Cancer: Germline Mutations in BRCA1 and BRCA2
by: Pankaja Umarane, et al.
Published: (2023-03-01)

Molecular Trajectory of BRCA1 and BRCA2 Mutations
by: Yuichiro Hatano, et al.
Published: (2020-03-01)

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands
by: Madeleine Bossaert, et al.
Published: (2021-06-01)

Predisposición genética para el cáncer de mama: genes BRCA1 y BRCA2 Genetic predisposition for breast cancer: BRCA1 and BRCA2 genes
by: Steven A Narod, et al.
Published: (2011-10-01)

ChatGPT and Bard in Plastic Surgery: Hype or Hope?
by: Ania Labouchère, et al.
Published: (2024-01-01)

BRCA1 and BRCA2 and Inherited Predisposition to Breast and Ovarian Cancers
by: Patricia N. Tonin
Published: (2002-12-01)

Post-transcriptional regulation of BRCA2 through interactions with miR-19a and miR-19b
by: Elena Mogilyansky, et al.
Published: (2016-08-01)

Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in <i>Streptococcus pneumoniae</i>
by: Miriam García-López, et al.
Published: (2023-10-01)

Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events
by: Lucy C. de Jong, et al.
Published: (2017-11-01)

Post-transcriptional regulation of BRCA1 through its coding sequence by the miR-15/107 group of miRNAs
by: Kevin eQuann, et al.
Published: (2015-07-01)