The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum

The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum

ABSTRACT Mycobacteria use specialized type VII secretion systems (T7SSs) to secrete proteins across their diderm cell envelope. One of the T7SS subtypes, named ESX-1, is a major virulence determinant in pathogenic species such as Mycobacterium tuberculosis and the fish pathogen Mycobacterium marinum...

Full description

Bibliographic Details
Main Authors: Merel P. M. Damen, Aniek S. Meijers, Esther M. Keizer, Sander R. Piersma, Connie R. Jiménez, Coenraad P. Kuijl, Wilbert Bitter, Edith N. G. Houben
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
ESX-1
EsxA
Mycobacterium
PPE
chaperones
protein transport
Online Access:https://journals.asm.org/doi/10.1128/mbio.02819-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02819-22

Similar Items