Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8+ T cells against SARS-CoV-2 variants

Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8+ T cells against SARS-CoV-2 variants

Summary: Recombinant vesicular stomatitis virus (rVSV) vaccines expressing spike proteins of Wuhan, Beta, and/or Delta variants of SARS-CoV-2 were generated and tested for induction of antibody and T cell immune responses following intramuscular delivery to mice. rVSV-Wuhan and rVSV-Delta vaccines a...

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Bibliographic Details
Main Authors: Kate A. Parham, Gyoung Nyoun Kim, Connor G. Richer, Marina Ninkov, Kunyu Wu, Nasrin Saeedian, Yue Li, Rasheduzzaman Rashu, Stephen D. Barr, Eric J. Arts, S.M. Mansour Haeryfar, C. Yong Kang, Ryan M. Troyer
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223003693

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223003693

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