BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be followed by cell-based assays. Here, we have developed a robu...

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Bibliographic Details
Main Authors: Nicolas Bery, Abimael Cruz-Migoni, Carole JR Bataille, Camilo E Quevedo, Hanna Tulmin, Ami Miller, Angela Russell, Simon EV Phillips, Stephen B Carr, Terence H Rabbitts
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
RAS
BRET
biosensors
protein-protein interaction inhibition
cell-based assays
intracellular antibody
Online Access:https://elifesciences.org/articles/37122

Internet

https://elifesciences.org/articles/37122

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