Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease

Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease

A Boolean network explorer (BoNE) computational algorithm was used to identify a dual agonist of the nuclear receptors PPARα and PPARγ that may be therapeutic in treating inflammatory bowel disease.

Bibliographic Details
Main Authors: Gajanan D. Katkar, Ibrahim M. Sayed, Mahitha Shree Anandachar, Vanessa Castillo, Eleadah Vidales, Daniel Toobian, Fatima Usmani, Joseph R. Sawires, Geoffray Leriche, Jerry Yang, William J. Sandborn, Soumita Das, Debashis Sahoo, Pradipta Ghosh
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03168-4

Internet

https://doi.org/10.1038/s42003-022-03168-4

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