Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

Converting resident glia into functional and subtype-specific neurons in vivo by delivering reprogramming genes directly to the brain provides a step forward toward the possibility of treating brain injuries or diseases. To date, it has been possible to obtain GABAergic and glutamatergic neurons via...

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Bibliographic Details
Main Authors: Maria Pereira, Marcella Birtele, Shelby Shrigley, Julio Aguila Benitez, Eva Hedlund, Malin Parmar, Daniella Rylander Ottosson
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
in vivo reprogramming
interneurons
striatum
NG2-glia
functional neurons
environmental effect
midbrain
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303338

Internet

http://www.sciencedirect.com/science/article/pii/S2213671117303338

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