The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila

The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila

Abstract cAMP Responsible Element Binding Protein (CREB) is an evolutionarily conserved transcriptional factor that regulates cell growth, synaptic plasticity and so on. In this study, we unexpectedly found proteasome inhibitors, such as MLN2238, robustly increase CREB activity in adult flies throug...

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Bibliographic Details
Main Authors: Youjie Yin, Peng Ma, Saifei Wang, Yao Zhang, Ruolei Han, Chunyu Huo, Meixian Wu, Hansong Deng
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05122-y

Internet

https://doi.org/10.1038/s41419-022-05122-y

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