3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies

3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies

Traditional studies using cancer cell lines are often performed on a two-dimensional (2D) cell culture model with a low success rate of translating to Phase I or Phase II clinical studies. In comparison, with the advent of developments three-dimensional (3D) cell culture has been championed as the l...

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Bibliographic Details
Main Authors: Huaikai Shi, Emma M. Rath, Ruby C. Y. Lin, Kadir Harun Sarun, Candice Julie Clarke, Brian C. McCaughan, Helen Ke, Anthony Linton, Kenneth Lee, Sonja Klebe, Joanneke Maitz, Kedong Song, Yiwei Wang, Steven Kao, Yuen Yee Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
3D spheroids
mesothelioma
tumor microenvironment
decellularized lung scaffold
microRNA expression
drug response and resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.973576/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.973576/full

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