NSC746364, a G-Quadruplex-Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells Through Activation of the ATR/Chk1-Dependent Pathway

NSC746364, a G-Quadruplex-Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells Through Activation of the ATR/Chk1-Dependent Pathway

Abstract.: The telomere is considered to be a potential target for cancer therapy. NSC746364, a novel G-quadruplex-stabilizing agent, has been found to have cytotoxic effects on various cancer cells. To date, its pharmacological mechanisms are still unknown. The goal of this study was to investigate...

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Bibliographic Details
Main Authors: Yun-Lung Chung, Chun-Hsu Pan, Wei-Hung Liou, Ming-Jyh Sheu, Wen-Hsin Lin, Tsung-Chih Chen, Hsu-Shan Huang, Chieh-Hsi Wu
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319302142

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http://www.sciencedirect.com/science/article/pii/S1347861319302142

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