Chiral Recognition R- and RS- of New Antifungal: Complexation/Solubilization/Dissolution Thermodynamics and Permeability Assay

Chiral Recognition R- and RS- of New Antifungal: Complexation/Solubilization/Dissolution Thermodynamics and Permeability Assay

Novel potential antifungal of 1,2,4-triazole class have been synthesized as pure enantiomer (R-98) and racemic (RS-186). The effect of 2-hydroxypropyl-β-cyclodextrin (<i>CD</i>) on the solubility and permeability of RS-186 and R-98 in terms of chiral recognition was investigated. Phase s...

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Bibliographic Details
Main Authors: Tatyana V. Volkova, Olga R. Simonova, Igor B. Levshin, German L. Perlovich
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
chiral discrimination
complexation
solubilization
dissolution
enantioselective transport
Online Access:https://www.mdpi.com/1999-4923/14/4/864

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https://www.mdpi.com/1999-4923/14/4/864

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