Natural Product-Based Drug Discovery – Epothilones as Lead Structures for the Discovery of New Anticancer Agents

Natural Product-Based Drug Discovery – Epothilones as Lead Structures for the Discovery of New Anticancer Agents

Epothilones are microtubule depolymerization inhibitors, which inhibit the growth of a broad range of human cancer cell lines in vitro with low nM or sub-nM IC50s. Unlike other cytotoxic anticancer agents, epothilones are also active in vitro against multidrug-resistant cell lines and they...

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Bibliographic Details
Main Authors: Karl-Heinz Altmann, Andreas Flörsheimera, Guido Bolda, Giorgio Caravattia, Markus Wartmanna
Format: Article
Language:deu
Published: Swiss Chemical Society 2004-10-01
Series:CHIMIA
Subjects:
Antiproliferative activity
Antitumor activity
Epothilones
Natural products
Structure activity relationships
Online Access:https://chimia.ch/chimia/article/view/3887

Internet

https://chimia.ch/chimia/article/view/3887

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