Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study

Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study

Abstract Background Although genetic risk factors and network-level neuroimaging abnormalities have shown effects on cognitive performance and brain atrophy in Alzheimer’s disease (AD), little is understood about how apolipoprotein E (APOE) ε4 allele, the best-known genetic risk for AD, affect brain...

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Bibliographic Details
Main Authors: Jin Li, Chenyuan Bian, Dandan Chen, Xianglian Meng, Haoran Luo, Hong Liang, Li Shen, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Bioinformatics
Subjects:
APOE ε4
Brain network
Persistent homology
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12859-020-03877-9

Internet

https://doi.org/10.1186/s12859-020-03877-9

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