(E)-5-Styryl-1H-indole and (E)-6-Styrylquinoline Derivatives Serve as Probes for β-Amyloid Plaques

(E)-5-Styryl-1H-indole and (E)-6-Styrylquinoline Derivatives Serve as Probes for β-Amyloid Plaques

We report the synthesis and biological evaluation of novel (E)-5-styryl-1H-indole and (E)-6-styrylquinoline derivatives as probes for imaging β-amyloid (Aβ) plaques. These derivatives showed binding affinities for Aβ1–40 aggregates with Ki values varying from 4.1 to 288.4 nM. (E)-5-(4-iodostyryl)-1H...

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Bibliographic Details
Main Authors: Bo-Li Liu, Hong-Mei Jia, Yang Yang
Format: Article
Language:English
Published: MDPI AG 2012-04-01
Series:Molecules
Subjects:
Alzheimer’s disease
β-amyloid plaques
binding affinity
imaging agent
SPECT
Online Access:http://www.mdpi.com/1420-3049/17/4/4252/

Internet

http://www.mdpi.com/1420-3049/17/4/4252/

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