PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

Summary: Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter resulted in invasive and ra...

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Bibliographic Details
Main Authors: M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Biological sciences
Metabolomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221015418

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http://www.sciencedirect.com/science/article/pii/S2589004221015418

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