Human α1-antitrypin binds to heat-shock protein gp96 and protects from endogenous gp96-mediated injury in vivo

Human α1-antitrypin binds to heat-shock protein gp96 and protects from endogenous gp96-mediated injury in vivo

The extracellular form of the abundant heat shock protein, gp96, is involved in human autoimmune pathologies. In patients with type 1 diabetes, circulating gp96 is found to be elevated, and is bound to the acute-phase protein, α1-antitrypsin (AAT). The two molecules also engage intracellularly durin...

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Bibliographic Details
Main Authors: Eli Chaim Lewis, David Elihai Ochayon, Mark Ilan Mizrahi, Galit eShahaf, Boris Michael Baranovski
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Immunology
Subjects:
Inflammation
Heat shock protein
diabetes
pancreatic islets
α1-antitrypsin
Allogeneic transplantation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00320/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00320/full

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