Rapid, Reference-Free human genotype imputation with denoising autoencoders

Rapid, Reference-Free human genotype imputation with denoising autoencoders

Genotype imputation is a foundational tool for population genetics. Standard statistical imputation approaches rely on the co-location of large whole-genome sequencing-based reference panels, powerful computing environments, and potentially sensitive genetic study data. This results in computational...

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Bibliographic Details
Main Authors: Raquel Dias, Doug Evans, Shang-Fu Chen, Kai-Yu Chen, Salvatore Loguercio, Leslie Chan, Ali Torkamani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
imputation
deep learning
artifitial intelligence
population genetics
genomics
autoencoder
Online Access:https://elifesciences.org/articles/75600

Internet

https://elifesciences.org/articles/75600

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